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5 octobre

Heure et lieu: 
11h, salle de réunion, bâtiment 210
Nom intervenant: 
Christopher Quince
Probabilistic Modelling of Microbial Community Structure

I will give an overview of methods that use generative probabilistic models to describe microbial community structure as determined through next generation sequencing. I will discuss the concept that the human gut microbiota is derived from a finite number of discrete types or enterotypes. I will show that Dirichlet-multinomial mixtures allow a more nuanced description of enterotypes as diffuse peaks in community configurations. I will then extend the idea of Dirichlet priors for community configurations to hierarchical Dirichlet processes which allow ‘unseen’ species to be modelled. I will use these both as a means for fitting the ecological model, Hubbell’s Unified Neutral Theory of Biodiversity, and for avoiding rarefaction in microbial community diversity estimation.

Organisme intervenant: 
Warwick Medical School, University of Warwick
Date du jour: 
Lundi, Octobre 5, 2015

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