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André-Leroux Gwenaëlle

Coordonnées

 

Email : gwenaelle.andre-leroux@inra.fr

DR2, PhD, HDR

Adresse : INRA - Unité MaIAGE
                   Bâtiment 233
                   Domaine de Vilvert
                   78352 JOUY-EN-JOSAS CEDEX
Tél : +33 (0)1 34 65 22 64

I work as a structural computational biologist at Inra, on the Campus of Jouy-en-Josas, in MaIAGE: Applied Mathematics and Computer Science, from Genome to Environment. This lab is headed by Dr. S. Schbath, and has a co-sharing divisions of MIA (Applied Mathematics and Informatics) and MICA (Microbiology and Food Chain). I belong to the StatInfoMics team headed by Dr. P. Nicolas. My interests deal with computational screening of whole genomes and metagenomes to infer proteins structures and functional annotations. I have special focus on proteins of the gut microbiome which are involved in biomedical properties such as host-pathogen or anti-inflammatory signaling. It is mainly prokaryotic signaling through phosphorylation and dephosphorylation events, mediated by protein Ser/Thr kinases and protein Tyr phosphatases, respectively. Also, it can be eukaryotic signaling with the study of odor Receptor that belong to the G-coupled Protein Receptor GPCR family. For all my projects, i combine structural and computational bioinformatics, molecular modeling expertise, X-ray crystallography skills, with in vitro/in vivo data from my collaborators, whose methods span biophysics, biochemistry, cellular biology, neurobiology, and immunology.

 

 

Main collaborations

  • Faculdad de Ciencias, Montevideo, Uruguay. Coll. A. Villarino & M. Berois. Inra MaIAGE M. Mariadassou. Projet Ecos-Sud Uruguay 2015: Characterization of the Tyrosine -phosphatase of the intracellular pathogen ORF-virus.

  • Unidad de Cristalografía de Proteínas. Instituto de Biología Molecular y Celular de Rosario IBR-CONICET-UNR, Argentina. M-N. Lisa. In silico characterization of the conservation of a signaling pathway mediated by PknG in Actinobacteria.
  • Institut Pasteur, Structural Microbiology Unit, Dir. Prof. P. Alzari. Coll. P. Alzari. Structural and functional characterization of PknB, essential Ser/Thr protein kinase of Mycobacterium tuberculosis. http://www.pasteur.fr/en/research/structural-biology-chemistry/units-gro....

  • Institut de Pharmacologie et de Biologie Structurale, Coll. H. Marrakchi & M. Daffé. Toulouse.  Structural and functional characterization of enzymes responsible for the biogenesis and degradation of mycolic acids in M. tuberculosis.

  • Institut Pasteur, Human genetics and Cognitive Functions Unit,  Dir. Prof. T. Bourgeron. Coll. I. Cloez-Tayarani. Towards structural insights on CNTN6 and Shank3.

 

Background

2012 - Senior Scientist at INRA Jouy-en-Josas, MaIAGE, StatInfOmics team.

2004-2012 Senior scientist detached at Institut Pasteur Paris, Structural Microbiology Unit.

2000-2004 Junior scientist INRA Nantes, BIA.

1999-2000 Cornell University, Ithaca, USA. Visiting assistant in Brady's lab https://foodscience.cals.cornell.edu/people/j-brady

1998 Inra, Nantes. PhD in Molecular Modeling, docking studies on Barley alpha-amylase.

 

Scientific Production 2013-2018*

 

* Wagner, T*., André-Leroux, G*.,Hindie, V., Barilone, N., Lisa, M-N., Le Normand, B., O’Hare, H., Bellinzoni M & Alzari, P.  Structural insights into the functional versatility of a FHA domain protein in mycobacterial sigaling. Submitted in Science Signaling.* equal contribution

 

* Lisa, M-N., Cvirkaite-Krupovic, V., Richet, E., André-Leroux, G., Alzari, P., HAOUZ, A., Danot O. Belt and suspenders: the double autoinhibition mechanism of Signal Transduction ATPases with Numerous Domains (STAND) with a tetratricopeptide repeat sensor. In revision in NAR.

 

* Altered spinogenesis in iPSC-derived cortical neurons from patients with autism carrying de novo SHANK3 mutations. Gouder, L., Vitrac, V., Goubran-Botros, H., Danckaert, A., Tinevez, J-Y., André-Leroux, G., Atanasova, E., Lemière, N., Biton, A., Leblond, C., Poulet, A., Boland, A., Deleuze, J-F., Benchoua, A., Delorme, R., Bourgeron, T. and Cloez-Tayarani, I. Accepted in Scientific Reports.

 

* Segovia, D., Haouz, A., Porley, D., Olivero, N., Martinez, M., Mariadassou, M., Berois, M., André-Leroux, G., Villarino, A. OH1 from Orf virus: a new tyrosine phosphatase that displays distinct structural features and triple substrate specificity. Journal of Molecular Biology, 26, 429 (2017).

 

* A. Collucia, G. La Regina, N. Barilone, M.N. Lisa, A. Brancale, G. André-Leroux, P.M. Alzari, Silvestri, R. Structure-based virtual screening to get news scaffold inhibitors of the Ser/Thr Protein Kinase PknB from Mycobacterium tuberculosis. Letters in Drug Design and Discovery, 2016, 13 (10) : 1012-1018.

 

* N. H. Le, V. Molle, N. Eynard, M. Miras, A. Stella, F. Bardou, S. Galladrin, V. guittet, G. André-Leroux, M. Bellinzoni, P. Alzari, L. Mourey, O. Burlet-Schiltz, M. Daffé, H. Marrakchi. Ser/Thr Phosphorylation regulates the Fatty Acyl-AMP ligase Activity of Fad32, an Essential Enzyme in Mycolic Acid Biosynthesis. J. Biol. Chem. 2016 oct 21; 291 (43): 22793-22805.

 

O. Mercati, G. Huguet, A. Danckaert, G. André-Leroux, A. Maruani, M. Bellinzoni, T. Rolland, L. Gouder, A. Mathieu, J. Buratti, F. Amsellem, M. Benabou, J. Van-Gils, A. Beggiato, M. Konyukh, J.P. Bourgeois, M.J. Gazzellone, R.K. Yuen, S. Walker, M. Delépine, A. Boland, B. Régnault, M. Francois, T. Van Den Abbeele, A. L. Mosca-Boidron, L. Faivre, Y. Shimoda, K. Watanabe, D. Bonneau, M. Rastam, M. Leboyer, S. W. Scherer, C. Gillberg, R. Delorme, I. Cloëz-Tayarani, T Bourgeron. CNTN6 mutations are risk factors for abnormal auditory sensory perception in autim spectrum disorders. Mol Psychiatry. 2016 May 10. doi: 10.1038/mp.2016.61.

 

* M. N. Schroeder*, M. V. Tribulatti*,J. Carabelli, G. André-Leroux, J. J. Caramelo, V. Cattaneo  & O. Campetella. Characterization of a double-CRD-mutated Gal-8 recombinant protein that retains costimulatory activity on antigen-specific T cell response. 2016, Biochemical Journal 473 (7) 887-898.


* M. N. Lisa, M. Gil, G. André-Leroux, N. Barilone, R. Duran, R.M Biondi  & P.M Alzari. Molecular basis of the activity and the regulation of the eukaryotic-like S/T protein kinase PknG from Mycobacterium tuberculosis. Structure. 2015 Jun 2;23(6):1039-48.

 

* M. Nefla, L. Sudre, G. Denat, S. Priam, G. Andre-Leroux, F. Berenbaum, C. Jacques. The Pro-inflammatory Cytokine s14-3-3e is a ligand of CD13/Aminopeptidase N in Cartilage. J Cell Sci. 2015 24. jcs 169573.

 

* E. Abi-Khalil, D. Segond, T. Terpstra, G. André-Leroux, M. Kallassy, D. Lereclus, F. Bou-Abdallah, C.E. Nielsen-Leroux.  Heme interplay between IlsA and IsdC: two structurally different interface proteins from Bacillus Cereus. Biochim Biophys Acta. 2015 Sep;1850(9):1930-41.

 

* A. Le Grand, G. André-Leroux, G. Marteil, H. Duval, O. Sire, V. Le Tilly. Investigating the in vitro Stability and Conformational Flexibility of Estrogen Receptors as Potentiel Key factors of their in vivo Activity. Biochemistry. 2015 Jun 30;54(25):3890-900.

 

* M. Bellinzoni, A. Haouz, I. Miras, S. Magnet, G. André-Leroux, R. Mukherjee, W. Shepard, S. Cole & P.M Alzari. Structural studies suggest a peptidoglycan hydrolase function for the Mycobacterium tuberculosis Tat-secreted protein rv2525. J Struct Biol. 2014 Nov;188(2):156-64.

 

M. Lucas-Hourani, D. Dauzonne, P. Jorda, G. Cousin, A. Lupan, O. Helynck, G. Caignard, G. Janvier, G. André-Leroux, N. Escriou, P. Desprès, Y. Jacob, H. Munier-Lehmann, F. Tangy and Pierre-Olivier Vidalain.. Inhibition of Pyridimine Biosynthesis Pathway Suppresses Viral Growth Through Innate Immunity.Plos Pathogens e1003678.

 

O. Mercati, A. Danckaert, L Gouder, G. André-Leroux, M. Bellinzoni, K. Watanabe, Y. Shimoda, R. Grailhe, F. de Chaumont, T. Bourgeron and I. Cloez-Tayarani. Contactin4, -5, -6 differentially regulate neuritogenesis while they display commun PTPRG binding sites. Biology 2013 2(3) : 324-34.

 

Chapitres d'ouvrages:

M. Martinez, P. M. Alzari and G. André-Leroux, 2013. Signalling mechanisms in Procaryotes, Chapter Book intitled ‘Bacterial Membranes: Structural and Molecular Biology’- edited by H Remaut and R. Fronzes, under printing in Horizon Scientific Press.

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