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Next seminars

  • 29 janvier 2018 11h, salle de réunion, bâtiment 210
    Elad Noor
    (ETH Zurich, Institute of Molecular Systems Biology)
    The Hidden costs of enzymatic catalysis
    The existence of a trade-off between the biomass yield and growth rate of cells has been used to explain aerobic fermentation in cancer cells (Warburg effect), yeast cells (Crabtree effect) and in bacteria such as E. coli. This trade-off relies on the assumption that even though fermentation pathways produce 5-10 times less ATP per glucose, respiration requires so much more resources and is therefore inefficient when carbon is not limiting. Is this trade-off a universal constraint imposed by thermodynamics, or a coincidental feature of the specific enzyme kinetic parameters that evolved in these organisms? To answer this question we developed a new method called Enzyme-Flux Cost Minimization (EFCM) to model the costs of both respiration and fermentation (along with ~1000 other flux combinations called elementary flux modes). We find that the trade-off in E. coli is not universal and depends strongly on the availability of oxygen. This framework successfully predicts in vivo enzyme concentrations, and has applications in metabolic engineering where similar candidate pathways can be compared not just by their yields, but also by their costs.
     
  • 12 février 2018 11h, salle de réunion, bâtiment 210
    Marc Chadeau-Hyam
    (Imperial College London, Faculty of Medicine, School of Public Health)
    Exposome research in practice: implementations, challenges and early results

    The accumulation of high-resolution molecular profiles using OMICS technologies have given rise to an unprecedented source of information to explore the effective biological effects of external stressors. Although the volume, dimensionality and complexity of OMICs data are constantly increasing, several robust methods enabling their analysis are now established. Such isolated exploration of an OMIC profile offers the possibility to capture of stressor-induced biochemical alterations but this may only yield a fractional picture of the complex molecular events involved. To explore molecular mechanisms mediating the effect of the exposome, three main methodological challenges arise: (i) OMICs data profiling and integration accommodating complex study designs, (ii) the exploration of molecular mechanisms involved in the exposure effect mediation, and (iii) the development of longitudinal models for disease risk and progression. In this presentation, we will describe possible methods to enable such OMIC analyses and ultimately unlock their full potential to provide insights into exposome-triggered molecular mechanisms affecting health.

  • 12 mars 2018 11h, salle de réunion, bâtiment 210
    TBA
    (TBA)
    TBA
  • 26 mars 2018 11h, salle de réunion, bâtiment 210
    Julie Josse
    (École Polytechnique, CMAP)
    TBA
  • 9 avril 2018 11h, salle de réunion, bâtiment 210
    Andreas Dräger
    (University of Tubingen, Applied Bioinformatics Group)
    TBA
  • 23 avril 2018 11h, salle de réunion, bâtiment 210
    TBA
    (TBA)
    TBA
  • 14 mai 2018 11h, salle de réunion, bâtiment 210
    Elie Desmond-Le Quéméner
    (INRA, UR 050 LBE)
    TBA
  • 28 mai 2018 11h, salle de réunion, bâtiment 210
    Zhanwu Dai
    (INRA, UMR EGFV, Centre Inra de Nouvelle-Aquitaine-Bordeaux )
    TBA
  • 11 juin 2018 11h, salle de réunion, bâtiment 210
    TBA
    (TBA)
    TBA


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by Dr. Radut